Structure of PDB 8c49 Chain A

Receptor sequence
>8c49A (length=274) Species: 1291540 (Methanomethylophilus alvi) [Search protein sequence]
VKYTDAQIQRLREYGNGTYEQKVFEDLASRDAAFSKEMSVASTDNEKKIK
GMIANPSRHGLTQLMNDIADALVAEGFIEVRTPIFISKDALARMTITEDK
PLFKQVFWIDEKRALRPMLAPNIFSVGRDLRDHTDGPVKIFEMGSCFRKE
SHSGMHLEEFTMLNLFDMGPRGDATEVLKNYISVVMKAAGLPDYDLVQEE
SDVFKETIDVEINGQEVCSAAVGPHYLDAAHDVHEPWSGAGFGLERLLTI
REKYSTVKKGGASISYLNGAKINL
3D structure
PDB8c49 Engineering mutually orthogonal PylRS/tRNA pairs for dual encoding of functional histidine analogues.
ChainA
Resolution1.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.26: pyrrolysine--tRNA(Pyl) ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A R150 E152 H158 L159 F162 M164 E218 V219 C220 S221 G243 G245 R248 R148 E150 H156 L157 F160 M162 E216 V217 C218 S219 G241 G243 R246
BS02 MG A E218 S221 E216 S219
BS03 MG A M120 L121 N166 M118 L119 N164
BS04 MG A D169 R173 D167 R171
Gene Ontology
Molecular Function
GO:0004812 aminoacyl-tRNA ligase activity
GO:0043767 pyrrolysyl-tRNA synthetase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:8c49, PDBe:8c49, PDBj:8c49
PDBsum8c49
PubMed37051694
UniProtM9SC49

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