Structure of PDB 8c47 Chain A

Receptor sequence
>8c47A (length=358) Species: 5664 (Leishmania major) [Search protein sequence]
SSIVCDNGSGMVKAGFSGDDAPRHVFPSIVGRPKVYVGDEAQSKRGVLSL
KYPIEHGIVTNWDDMEKIWHHTFYNELRVNPEQHNVLLTEAPMNPKQNRE
KMTQIMFETFNVPSLYIGIQAVLSLYSSGRTTGIVLDAGDGVTHTVPIYE
GYSLPHAVRRVDMAGRDLTEYLMKIMMETGTTFTTTAEKEIVRNVKEQLC
YVALDFEEEMTNSAKSANEEAFELPDGNVMMVGNQRFRCPEVLFKPSLIG
LDEAPGFPEMVYQSINKCDIDVRRELYGNIVLSGGSTMFLNLPERLAKEI
SNLAPSSIKPKVVAPPERKYSVWIGGSILSSLTTFQTMWVKKSEYDESGP
SIVHNKCF
3D structure
PDB8c47 Leishmania profilin interacts with actin through an unusual structural mechanism to control cytoskeletal dynamics in parasites.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A G13 S14 G15 K18 G156 D157 G158 V159 G182 K213 E214 G302 M305 F306 G8 S9 G10 K13 G139 D140 G141 V142 G165 K196 E197 G285 M288 F289
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016787 hydrolase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:8c47, PDBe:8c47, PDBj:8c47
PDBsum8c47
PubMed38340794
UniProtP45520|ACT_LEIMA Actin

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