Structure of PDB 8c3o Chain A

Receptor sequence
>8c3oA (length=794) Species: 9606 (Homo sapiens) [Search protein sequence]
ISGSCKGRCFELQEAGPPDCRCDNLCKSYTSCCHDFDELCLKTARGWECT
KDRCGEVRNEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKA
AECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRP
VYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRW
WGGQPLWITATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHERPSVY
AFYSEQPDFSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNV
IFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYD
PKAIIAALTCKKPDQHFKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHV
ARKPLDVYKCFFQGDHGFDNKVNSMQTVFVGYGSTFKYKTKVPPFENIEL
YNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPEEVTRPNYPGIMYL
QSDFDLGCTCDDPKNKLDELNKRLHTKERHLLYGRPAVLYRTRYDILYHT
DFESGYSEIFLMPLWTSYTVSKQAEVSSVPDHLTSCVRPDVRVSPSFSQN
CLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWNYF
QRVLVKKYASERNGVNVISGPIFDYDYDGLHDTEDKIKQYVEGSSIPVPT
HYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNEESCNSSEDESKWV
EELMKMHTARVRDIEHLTSLDFFRKTSRSYPEILTLKTYLHTYE
3D structure
PDB8c3o Discovery of potent chromone-based autotaxin inhibitors inspired by cannabinoids.
ChainA
Resolution2.47 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.39: alkylglycerophosphoethanolamine phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5JK A S82 Y215 F250 W255 P259 I262 F275 S28 Y161 F196 W201 P205 I208 F221
BS02 T8R A L214 Y215 W255 F275 W276 Y307 L160 Y161 W201 F221 W222 Y253
BS03 ZN A D312 H316 H475 D258 H262 H416
BS04 ZN A D172 T210 D359 H360 D118 T156 D305 H306
BS05 CA A D765 D767 D769 L771 D773 D674 D676 D678 L680 D682
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005044 scavenger receptor activity
GO:0016787 hydrolase activity
GO:0030247 polysaccharide binding
GO:0046872 metal ion binding
Biological Process
GO:0006955 immune response

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Molecular Function
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Biological Process
External links
PDB RCSB:8c3o, PDBe:8c3o, PDBj:8c3o
PDBsum8c3o
PubMed37976710
UniProtQ13822|ENPP2_HUMAN Autotaxin (Gene Name=ENPP2)

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