Structure of PDB 8c3d Chain A

Receptor sequence
>8c3dA (length=215) Species: 9606 (Homo sapiens) [Search protein sequence]
APDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSP
QNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNP
TGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVY
YDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNK
NNACGIANLASFPKM
3D structure
PDB8c3d Sulfonated Calpeptin is a promising drug candidate against SARS-CoV-2 infections
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.38: cathepsin K.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A G23 C25 D61 G64 G65 G66 G23 C25 D61 G64 G65 G66
BS02 CA A E59 N70 Q73 E59 N70 Q73
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8c3d, PDBe:8c3d, PDBj:8c3d
PDBsum8c3d
PubMed37853179
UniProtP43235|CATK_HUMAN Cathepsin K (Gene Name=CTSK)

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