Structure of PDB 8c2z Chain A

Receptor sequence
>8c2zA (length=334) Species: 9606 (Homo sapiens) [Search protein sequence]
LNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELV
AIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLC
LVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIH
CDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLG
TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAML
DQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVGHSPAD
YLRFQDLVLRMLEYEPAARISPLGALQHGFFRRT
3D structure
PDB8c2z Structural perspective on the design of selective DYRK1B inhibitors
ChainA
Resolution1.91 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QS0 A I117 V125 A138 K140 L192 L193 S194 D199 L246 V258 I30 V38 A51 K53 L105 L106 S107 D112 L159 V171
BS02 MN A D239 D259 D152 D172
BS03 MN A E160 H179 E73 H92
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0046777 protein autophosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8c2z, PDBe:8c2z, PDBj:8c2z
PDBsum8c2z
PubMed
UniProtQ9Y463|DYR1B_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 1B (Gene Name=DYRK1B)

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