Structure of PDB 8c2o Chain A

Receptor sequence
>8c2oA (length=228) Species: 562 (Escherichia coli) [Search protein sequence]
GKRVVVLDPGHGGIDTGAIGRNGSKEKHVVLAIAKNVRSILRNHGIDARL
TRSGDTFIPLYDRVEIAHKHGADLFMSIHADGFTNPKAAGASVFALSNRG
ASSAMAKYLSERENRADEVAGKKATDKDHLLQQVLFDLVQTDTIKNSLTL
GSHILKKIKPVHKLHSRNTEQAAFVVLKSPSVPSVLVETSFITNPEEERL
LGTAAFRQKIATAIAEGVISYFHWFDNQ
3D structure
PDB8c2o Activator-induced conformational changes regulate division-associated peptidoglycan amidases.
ChainA
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.28: N-acetylmuramoyl-L-alanine amidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H65 E80 H133 D135 E167 H11 E26 H79 D81 E113
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0009253 peptidoglycan catabolic process
GO:0051301 cell division
GO:0071236 cellular response to antibiotic
GO:0071555 cell wall organization
Cellular Component
GO:0030288 outer membrane-bounded periplasmic space
GO:0042597 periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8c2o, PDBe:8c2o, PDBj:8c2o
PDBsum8c2o
PubMed37276423
UniProtP36548|AMIA_ECOLI N-acetylmuramoyl-L-alanine amidase AmiA (Gene Name=amiA)

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