Structure of PDB 8c1i Chain A

Receptor sequence

>8c1iA (length=260) Species: 9606 (Homo sapiens)

RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVE
HQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKL
SKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADF
GWSVHAPSSRRTGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPP
FEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVL
EHPWITANSS

3D structure

• PDB: 8c1i Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agent
• Chain: A
• Resolution: 2.81 Å

Enzymatic activity

• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	A	G140 G142 K143 V147 A160 K162 A213 T217 E260 L263 D274	G15 G17 K18 V22 A35 K37 A88 T92 E135 L138 D149
BS02	MG	A	N261 D274	N136 D149
BS03	T1L	A	K166 E170 R179 Y199 F200 H201 V206	K41 E45 R54 Y74 F75 H76 V81
BS04	T5L	A	F144 K162 L164 V174 Q177 E181 G276 W277	F19 K37 L39 V49 Q52 E56 G151 W152

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:8c1i, PDBe:8c1i, PDBj:8c1i
• PDBsum: 8c1i
• PubMed: 39190548
• UniProt: O14965|AURKA_HUMAN Aurora kinase A (Gene Name=AURKA)