Structure of PDB 8c1g Chain A

Receptor sequence
>8c1gA (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
QWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEH
QLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLS
KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFG
WSVHAPSSRRGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFE
ANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEH
PWITANSS
3D structure
PDB8c1g Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agent
ChainA
Resolution1.96 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 T3I A K166 E170 L178 R179 H201 V206 K40 E44 L52 R53 H75 V80
BS02 ADP A L139 G142 K143 V147 A160 K162 A213 T217 E260 L263 D274 L13 G16 K17 V21 A34 K36 A87 T91 E134 L137 D148
BS03 MG A N261 D274 N135 D148
BS04 T5L A F144 K162 L164 V174 Q177 E181 G276 W277 F18 K36 L38 V48 Q51 E55 G150 W151
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8c1g, PDBe:8c1g, PDBj:8c1g
PDBsum8c1g
PubMed39190548
UniProtO14965|AURKA_HUMAN Aurora kinase A (Gene Name=AURKA)

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