Structure of PDB 8c1d Chain A

Receptor sequence
>8c1dA (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
QWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEH
QLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLS
KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFG
WSVHAPSSRRTGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPF
EANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLE
HPWITANSS
3D structure
PDB8c1d Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agent
ChainA
Resolution2.115 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 T2F A K166 E170 L178 R179 K40 E44 L52 R53
BS02 ADP A G140 G142 K143 V147 A160 K162 A213 T217 E260 L263 D274 G14 G16 K17 V21 A34 K36 A87 T91 E134 L137 D148
BS03 MG A N261 D274 N135 D148
BS04 T5L A F144 K162 L164 V174 Q177 E181 G276 W277 F18 K36 L38 V48 Q51 E55 G150 W151
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:8c1d, PDBe:8c1d, PDBj:8c1d
PDBsum8c1d
PubMed39190548
UniProtO14965|AURKA_HUMAN Aurora kinase A (Gene Name=AURKA)

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