Structure of PDB 8c15 Chain A

Receptor sequence
>8c15A (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVE
HQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKL
SKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADF
GWSVHAPSSRRGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPF
EANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLE
HPWITANSS
3D structure
PDB8c15 Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agents
ChainA
Resolution2.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G142 K143 V147 A160 K162 A213 T217 E260 L263 D274 G17 K18 V22 A35 K37 A88 T92 E135 L138 D149
BS02 MG A N261 D274 N136 D149
BS03 T4C A K166 E170 L178 R179 H201 V206 K41 E45 L53 R54 H76 V81
BS04 T5L A F144 K162 L164 V174 Q177 E181 G276 W277 F19 K37 L39 V49 Q52 E56 G151 W152
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8c15, PDBe:8c15, PDBj:8c15
PDBsum8c15
PubMed39190548
UniProtO14965|AURKA_HUMAN Aurora kinase A (Gene Name=AURKA)

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