Structure of PDB 8c0g Chain A

Receptor sequence
>8c0gA (length=289) Species: 694009 (Severe acute respiratory syndrome-related coronavirus) [Search protein sequence]
SQAWQPGVAMPNLYKMQRMLLEKCDLQNYGENAVIPKGIMMNVAKYTQLC
QYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLN
DFVSDADSTLIGDCATVHTANKWDLIISDMYDPRTKHVTKENDSKEGFFT
YLCGFIKQKLALGGSIAVKITEHSWNADLYKLMGHFSWWTAFVTNVNASS
SEAFLIGANYLGKPKEQIDGYTMHANYIFWRNTNPIQLSSYSLFDMSKFP
LKLRGTAVMSLKENQINDMIYSLLEKGRLIIRENNRVVV
3D structure
PDB8c0g Observation of N7-GTP in nsp16-nsp10 Sars-CoV
ChainA
Resolution1.88 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SRC A L56 T57 S187 W188 L56 T57 S187 W188
Gene Ontology
Molecular Function
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:8c0g, PDBe:8c0g, PDBj:8c0g
PDBsum8c0g
PubMed
UniProtP0C6X7|R1AB_SARS Replicase polyprotein 1ab (Gene Name=rep)

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