Structure of PDB 8c05 Chain A

Receptor sequence
>8c05A (length=305) Species: 2051956 (Methylotenera sp.) [Search protein sequence]
QYLLEAIVRDARDGITISDCSRPDNPLVFVNDAFTRMTGYDAEEVIGKNC
RFLQRGDINLSAVHTIKIAMLTHEPCLVTLKNYRKDGTIFWNELSLTPII
NKNGLITHYLGIQKDVSAQVILNQTLHEENSNKEMLEYLVNIDALTGLHN
RRFLEDQLVIQWKLASRHINTITIFMIDIDYFKAFNDTYGHTAGDEALRT
IAKTLNNCFMRGSDFVARYGGEEFTILAIGMTELQAHEYSTKLVQKIENL
NIHHKGSPLGHLTISLGYSQANPQYHNDQNLVIEQADRALYSAKVEGKNR
AVAYR
3D structure
PDB8c05 Illuminating the inner workings of a natural protein switch: Blue-light sensing in LOV-activated diguanylate cyclases.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.65: diguanylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN A T19 S21 N52 C53 R54 L56 Q57 V66 M73 L83 N85 N95 L97 L99 Q116 T16 S18 N49 C50 R51 L53 Q54 V63 M70 L80 N82 N92 L94 L96 Q113
BS02 MG A D185 I186 E229 D178 I179 E222
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0046872 metal ion binding
GO:0052621 diguanylate cyclase activity
Biological Process
GO:0043709 cell adhesion involved in single-species biofilm formation
GO:1902201 negative regulation of bacterial-type flagellum-dependent cell motility
Cellular Component
GO:0005886 plasma membrane

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Cellular Component
External links
PDB RCSB:8c05, PDBe:8c05, PDBj:8c05
PDBsum8c05
PubMed37531459
UniProtA0A2S5LZS0

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