Structure of PDB 8bzx Chain A

Receptor sequence
>8bzxA (length=546) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
DIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASG
LGTVELTVALHYVYNTPFDRLIWDVGHQAYPHKILTGRRDKIGTIRQKGG
LHPFPWRGESEYDVLSVGHSSTSISAGIGVAIAAAKEDKQRRAVCVIGDG
AITAGMAFEAMNHAGDIKPDLLVVLNDNEMSISENVGALGPGTLFEELGF
NYIGPVDGHDVLGLVSTLKNMRDLKGPQFLHIMTKKGRGYEPGLPSYSKI
FGDWLCETAAKDNKLMAITPAMREGSGMVEFSKKFPDRYFDVAIAEQHAV
TFAAGLAIGDYKPVVAIYSTFLQRAYDQVIHDVAIQKLPVLFAIDRAGIV
GADGQTHQGAFDLSFLRCIPDMVVMTPSDENECRQMLYTGYHYSDGPCAV
RYPRGSGTGATLEPLASLPIGKGVVKRQGEKIAILNFGTLLPEAAAVADK
LNATLVDMRFVKPLDTALILQLAGEHDALVTLEENAIMGGAGSGVNEVLM
AHRRAVPVLNIGLPDYFIPQGTQEEIRADLGLDAAGIEAKIRDWLA
3D structure
PDB8bzx Design of thiamine analogues for inhibition of thiamine diphosphate (ThDP)-dependent enzymes: Systematic investigation through Scaffold-Hopping and C2-Functionalisation.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.2.1.7: 1-deoxy-D-xylulose-5-phosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SW6 A H80 F107 S123 G151 D152 G153 A154 S184 I185 M312 I334 E336 F361 R364 H397 H77 F104 S120 G148 D149 G150 A151 S181 I182 M272 I294 E296 F321 R324 H357
BS02 MG A D152 N181 M183 D149 N178 M180
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity
Biological Process
GO:0016114 terpenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8bzx, PDBe:8bzx, PDBj:8bzx
PDBsum8bzx
PubMed37201323
UniProtA6T5F3|DXS_KLEP7 1-deoxy-D-xylulose-5-phosphate synthase (Gene Name=dxs)

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