Structure of PDB 8by2 Chain A

Receptor sequence
>8by2A (length=548) Species: 562 (Escherichia coli) [Search protein sequence]
MDSHTLIQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVT
DAESILHFAEIGVVLMLFIIGLELDPQRLWKLRAAVFGGGALQMVICGGL
LGLFCMLLGLRWQVAELIGMTLALSSTAIAMQAMNERNLMVTQMGRSAFA
VLLFQDIAAIPLVAMIPLLATSSASTTMGAFALSALKVAGALVLVVLLGR
YVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLSMAMGAFLAGV
LLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLLENPLRIVILL
LGFLIIKIAMLWLIARPLQVPNKQRRWFAVLLGQGSEFAFVVFGAAQMAN
VLEPEWAKSLTLAVALSMAATPILLVILNRLEQSSEQPRVIIAGFGRFGQ
ITGRLLLSSGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAA
KAEVLINAIDDPQTNLQLTEMVKEHFPHLQIIARARDVDHYIRLRQAGVE
KPERETFEGALKTGRLALESLGLGPYEARERADVFRRFNIQMVEEMAM
3D structure
PDB8by2 Structure and mechanism of the K+/H+ exchanger KefC
ChainA
Resolution3.18 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K A S125 T127 L152 Q155 D156 S125 T127 L152 Q155 D156
BS02 AMP A F407 R409 H430 D431 D449 A450 I471 R496 F395 R397 H418 D419 D437 A438 I459 R484
BS03 GSH A R409 I413 R397 I401
BS04 PGW A E53 H57 E53 H57
BS05 GSH A R498 D499 R486 D487
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0008324 monoatomic cation transmembrane transporter activity
GO:0015079 potassium ion transmembrane transporter activity
GO:0015297 antiporter activity
GO:0015503 glutathione-regulated potassium exporter activity
GO:0015643 toxic substance binding
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006812 monoatomic cation transport
GO:0006813 potassium ion transport
GO:0006885 regulation of pH
GO:0009636 response to toxic substance
GO:0042542 response to hydrogen peroxide
GO:0051453 regulation of intracellular pH
GO:0051454 intracellular pH elevation
GO:0051595 response to methylglyoxal
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:1903103 potassium:proton antiporter complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8by2, PDBe:8by2, PDBj:8by2
PDBsum8by2
PubMed38834573
UniProtP03819|KEFC_ECOLI Glutathione-regulated potassium-efflux system protein KefC (Gene Name=kefC)

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