Structure of PDB 8bwu Chain A

Receptor sequence
>8bwuA (length=261) Species: 9606,2697049 [Search protein sequence]
RLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLT
KEDFRYRSPHSGDELYELLQHILKQPAAGDELKINAACRKVQHMVVKAAL
LADKFPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSDKAYKIEELFYSYA
THSDKFTDGVCLFWNCNVDRYPANSIVCRFSAFVNLKQLPFFYYSDSPCE
SHVPLKSATCITRCNLGGAVCRHHANEYRLYLDAYNMMISAGFSLWVYKQ
FDTYNLWNTFT
3D structure
PDB8bwu Crystal structure of SARS-CoV-2 nsp14 methyltransferase domain in complex with the SS148 inhibitor
ChainA
Resolution2.36 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6NR A G333 P335 D352 A353 L366 F367 Y368 W385 C387 N388 G112 P114 D131 A132 L145 F146 Y147 W164 C166 N167
BS02 ZN A C452 C477 H487 C199 C214 H224
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004532 RNA exonuclease activity
GO:0008168 methyltransferase activity
GO:0043565 sequence-specific DNA binding

View graph for
Molecular Function
External links
PDB RCSB:8bwu, PDBe:8bwu, PDBj:8bwu
PDBsum8bwu
PubMed
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep);
P41212|ETV6_HUMAN Transcription factor ETV6 (Gene Name=ETV6)

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