Structure of PDB 8bw7 Chain A

Receptor sequence
>8bw7A (length=497) Species: 10116 (Rattus norvegicus) [Search protein sequence]
MAFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPPHHCR
PPANANLSKDGGLEAWLPLDKQGQPESCLRFTSTEPCIDGWVYDNSTFPS
TIVTEWNLVCSHRAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILN
YLQTAVSGTCAAYAPNYTVYCVFRLLSGMSLASIAINCMTLNVEWMPIHT
RAYVGTLIGYVYSLGQFLLAGIAYAVPHWRHLQLVVSVPFFIAFIYSWFF
IESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSIEVLRTSLQSAME
LLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVD
LPAKFVCFLVINSMGRRPAQMASLLLAGICILVNGIIPKSHTIIRTSLAV
LGKGCLASSFNCIFLYTGELYPTVIRQTGLGMGSTMARVGSIVSPLVSMT
AEFYPSMPLFIFGAVPVVASAVTALLPETLGQPLPDTVQDLKSRSRG
3D structure
PDB8bw7 Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1.
ChainA
Resolution3.53 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AKG A G227 Y230 K382 G209 Y212 K354
Gene Ontology
Molecular Function
GO:0005452 solute:inorganic anion antiporter activity
GO:0005515 protein binding
GO:0008514 organic anion transmembrane transporter activity
GO:0015132 prostaglandin transmembrane transporter activity
GO:0015139 alpha-ketoglutarate transmembrane transporter activity
GO:0015297 antiporter activity
GO:0015347 sodium-independent organic anion transmembrane transporter activity
GO:0022857 transmembrane transporter activity
GO:0031404 chloride ion binding
GO:0042802 identical protein binding
GO:0042910 xenobiotic transmembrane transporter activity
Biological Process
GO:0006820 monoatomic anion transport
GO:0014070 response to organic cyclic compound
GO:0015698 inorganic anion transport
GO:0015711 organic anion transport
GO:0015732 prostaglandin transport
GO:0015742 alpha-ketoglutarate transport
GO:0042908 xenobiotic transport
GO:0043252 sodium-independent organic anion transport
GO:0055085 transmembrane transport
GO:0072237 metanephric proximal tubule development
GO:0097254 renal tubular secretion
Cellular Component
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0032991 protein-containing complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8bw7, PDBe:8bw7, PDBj:8bw7
PDBsum8bw7
PubMed37482561
UniProtO35956|S22A6_RAT Solute carrier family 22 member 6 (Gene Name=Slc22a6)

[Back to BioLiP]