Structure of PDB 8buz Chain A

Receptor sequence
>8buzA (length=890) Species: 9913 (Bos taurus) [Search protein sequence]
SRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLK
GILLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGL
GYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLMQVVLQAVIPR
LAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLR
LETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYEN
VSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILG
DCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHS
GSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGD
YNVEEGHGKERNEFLRKHNIKRIEHTIDLRSGDKLRREHIKPFSLMFKDS
SLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMAIQFSIL
IMLHSALVLITTAEDYKCLPLVLRKTCCWINETYLARNVIIFASILINFL
GAILNILWCDCSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIY
ALLTETIYAGLFLRYDNLNHSGEDFLGTKEASLLLMAMFLLAVFYHGQQL
EYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRD
NEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFD
ELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKWGHLCALADFSLALTESIQ
EINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTG
VSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKI
3D structure
PDB8buz Structure of Adenylyl cyclase 8 bound to stimulatory G-protein, Ca2+/Calmodulin, Forskolin and MANT-GTP
ChainA
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FOK A W532 S533 D537 S1040 W368 S369 D373 S769
Gene Ontology
Molecular Function
GO:0004016 adenylate cyclase activity
GO:0005524 ATP binding
GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity
GO:0016829 lyase activity
GO:0016849 phosphorus-oxygen lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006171 cAMP biosynthetic process
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007613 memory
GO:0007616 long-term memory
GO:0007626 locomotory behavior
GO:0009190 cyclic nucleotide biosynthetic process
GO:0010255 glucose mediated signaling pathway
GO:0031915 positive regulation of synaptic plasticity
GO:0032024 positive regulation of insulin secretion
GO:0032793 positive regulation of CREB transcription factor activity
GO:0035556 intracellular signal transduction
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042593 glucose homeostasis
GO:0050804 modulation of chemical synaptic transmission
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0071315 cellular response to morphine
GO:0071377 cellular response to glucagon stimulus
GO:0080135 regulation of cellular response to stress
GO:0150076 neuroinflammatory response
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1900454 positive regulation of long-term synaptic depression
Cellular Component
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0032809 neuronal cell body membrane
GO:0042734 presynaptic membrane
GO:0048786 presynaptic active zone
GO:0060076 excitatory synapse
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098686 hippocampal mossy fiber to CA3 synapse
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8buz, PDBe:8buz, PDBj:8buz
PDBsum8buz
PubMed38351373
UniProtE1BQ12

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