Structure of PDB 8bsk Chain A

Receptor sequence
>8bskA (length=308) Species: 9606 (Homo sapiens) [Search protein sequence]
PDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQ
RHSTGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLKLFLN
EDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFS
NATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTC
ESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAF
HVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSL
CNFHNYDN
3D structure
PDB8bsk Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.2: glutaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 04A A K320 L321 F322 L323 N324 E325 Y394 K96 L97 F98 L99 N100 E101 Y170
Gene Ontology
Molecular Function
GO:0004359 glutaminase activity
Biological Process
GO:0006541 glutamine metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8bsk, PDBe:8bsk, PDBj:8bsk
PDBsum8bsk
PubMed31199640
UniProtO94925|GLSK_HUMAN Glutaminase kidney isoform, mitochondrial (Gene Name=GLS)

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