Structure of PDB 8br4 Chain A

Receptor sequence

>8br4A (length=339) Species: 1773 (Mycobacterium tuberculosis)

MTVRVGINGFGRIGRNFYRALLAQQEQGTADVEVVAANDITDNSTLAHLL
KFDSILGRLPCDVGLEGDDTIVVGRAKIKALAVREGPAALPWGDLGVDVV
VESTGLFTNAAKAKGHLDAGAKKVIISAPATDEDITIVLGVNDDKYDGSQ
NIISNASCTTNCLAPLAKVLDDEFGIVKGLMTTIHAYTQDQNLQDGPHKD
LRRARAAALNIVPTSTGAAKAIGLVMPQLKGKLDGYALRVPIPTGSVTDL
TVDLSTRASVDEINAAFKAAAEGRLKGILKYYDAPIVSSDIVTDPHSSIF
DSGLTKVIDDQAKVVSWYDNEWGYSNRLVDLVTLVGKSL

3D structure

• PDB: 8br4 Structure of GAPDH from Mycobacterium tuberculosis
• Chain: A
• Resolution: 3.29 Å

Enzymatic activity

• Enzyme Commision number: 1.2.1.12: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	A	G9 G11 R12 I13 N38 D39 S103 T104 G105 S127 C158 N320 Y324	G9 G11 R12 I13 N38 D39 S103 T104 G105 S127 C158 N320 Y324

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
• GO:0016491 oxidoreductase activity
• GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
• GO:0050661 NADP binding
• GO:0051287 NAD binding

Biological Process

• GO:0006006 glucose metabolic process
• GO:0006096 glycolytic process

Cellular Component

• GO:0005576 extracellular region
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005886 plasma membrane
• GO:0009274 peptidoglycan-based cell wall

External links

• PDB: RCSB:8br4, PDBe:8br4, PDBj:8br4
• PDBsum: 8br4
• UniProt: P9WN83|G3P_MYCTU Glyceraldehyde-3-phosphate dehydrogenase (Gene Name=gap)