Structure of PDB 8bqh Chain A

Receptor sequence

>8bqhA (length=955) Species: 882 (Nitratidesulfovibrio vulgaris str. Hildenborough)

KQTTSICCYCAVGCGLIVHTAKDGQGRAVNVEGDPDHPINEGSLCPKGAS
IFQLGENDQRGTQPLYRAPFSDTWKPVTWDFALTEIAKRIKKTRDASFTE
KNAAGDLVNRTEAIASFGSAAMDNEECWAYGNILRSLGLVYIEHQARICH
SPTVPALAESFGRGAMTNHWNDLANSDCILIMGSNAAENHPIAFKWVLRA
KDKGATLIHVDPRFTRTSARCDVYAPIRSGADIPFLGGLIKYILDNKLYF
TDYVREYTNASLIVGEKFSFKDGLFSGYDAANKKYDKSMWAFELDANGVP
KRDPALKHPRCVINLLKKHYERYNLDKVAAITGTSKEQLQQVYKAYAATG
KPDKAGTIMYAMGWTQHSVGVQNIRAMAMIQLLLGNIGVAGGGVNALRGE
SNVQGSTDQGLLAHIWPGYNPVPNSKAATLELYNAATPQSKDPMSVNWWQ
NRPKYVASYLKALYPDEEPAAAYDYLPRIDAGRKLTDYFWLNIFEKMDKG
EFKGLFAWGMNPACGGANANKNRKAMGKLEWLVNVNLFENETSSFWKGPG
MNPAEIGTEVFFLPCCVSIEKEGSVANSGRWMQWRYRGPKPYAETKPDGD
IMLDMFKKVRELYAKEGGAYPAPIAKLNIADWEEHNEFSPTKVAKLMNGY
FLKDTEVGGKQFKKGQQVPSFAFLTADGSTCSGNWLHAGSFTDAGNLMAR
RDKTQTPEQARIGLFPNWSFCWPVNRRILYNRASVDKTGKPWNPAKAVIE
WKDGKWVGDVVDGGGDPGTKHPFIMQTHGFGALYGPGREEGPFPEHYEPL
ECPVSKNPFSKQLHNPVAKAVCDPRYPFIGTTYRVTEHWQTGLMTRRCAW
LVEAEPQIFCEISKELAKLRGIGNGDTVKVSSLRGALEAVAIVTERIRPF
KIEGVDVHMVGLPWHYGWMVPKNGGDTANLLTPSAGDPNTGIPETKAFMV
DVRKV

3D structure

• PDB: 8bqh Tracking W-Formate Dehydrogenase Structural Changes During Catalysis and Enzyme Reoxidation.
• Chain: A
• Resolution: 1.61 Å

Enzymatic activity

• Enzyme Commision number: 1.2.1.2: Transferred entry: 1.17.1.9.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MGD	A	K90 U192 S227 N228 N232 D254 P255 R256 S272 D275 A404 M405 G406 W407 G442 Y883 R884 T886 H888 W889 Q890	K47 U149 S184 N185 N189 D211 P212 R213 S229 D232 A361 M362 G363 W364 G399 Y833 R834 T836 H838 W839 Q840
BS02	MGD	A	A164 Q188 U192 M405 G552 M553 N554 G558 N579 C608 K614 D641 T882 R884 Q890 T891 L893 M894 W964 N979 T995 K996	A121 Q145 U149 M362 G509 M510 N511 G515 N536 C565 K571 D598 T832 R834 Q840 T841 L843 M844 W914 N929 T945 K946
BS03	SF4	A	C50 C53 V55 C57 L87 C88 G91 P234 I235	C7 C10 V12 C14 L44 C45 G48 P191 I192

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0008863 formate dehydrogenase (NAD+) activity
• GO:0009055 electron transfer activity
• GO:0016491 oxidoreductase activity
• GO:0030151 molybdenum ion binding
• GO:0043546 molybdopterin cofactor binding
• GO:0046872 metal ion binding
• GO:0047111 formate dehydrogenase (cytochrome-c-553) activity
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:0009061 anaerobic respiration
• GO:0045333 cellular respiration

Cellular Component

• GO:0042597 periplasmic space

External links

• PDB: RCSB:8bqh, PDBe:8bqh, PDBj:8bqh
• PDBsum: 8bqh
• PubMed: 36613918
• UniProt: Q72EJ1