Structure of PDB 8bq4 Chain A

Receptor sequence
>8bq4A (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
DPLVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENL
PSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESERFLISYDRT
LVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDS
YMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNK
NQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIDVYAIRS
AEGAPQKEVYFMGLIDILVHPEQYAKRFLDFITNI
3D structure
PDB8bq4 The Identification of Potent, Selective, and Brain Penetrant PI5P4K gamma Inhibitors as In Vivo-Ready Tool Molecules.
ChainA
Resolution2.42 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.149: 1-phosphatidylinositol-5-phosphate 4-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QZR A K152 M203 N205 M206 F207 L284 I373 L376 K104 M155 N157 M158 F159 L236 I265 L268
Gene Ontology
Molecular Function
GO:0052742 phosphatidylinositol kinase activity
Biological Process
GO:0046488 phosphatidylinositol metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8bq4, PDBe:8bq4, PDBj:8bq4
PDBsum8bq4
PubMed36516442
UniProtQ8TBX8|PI42C_HUMAN Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (Gene Name=PIP4K2C)

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