Structure of PDB 8bom Chain A

Receptor sequence
>8bomA (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
TTEIHPSCVTRQKVIGAGEFGEVYKGMLKEVPVAIKTLKAGYTEKQRVDF
LGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGE
FSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGL
PIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKA
INDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPD
SLKTLADFDPRVSIRLP
3D structure
PDB8bom Optimization of the Lead Compound NVP-BHG712 as a Colorectal Cancer Inhibitor.
ChainA
Resolution1.12 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QU6 A V627 A644 E663 M667 F670 I676 I690 T692 Y694 Y735 L746 S756 D757 F758 V23 A34 E53 M57 F60 I66 I80 T82 Y84 Y125 L136 S146 D147 F148
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8bom, PDBe:8bom, PDBj:8bom
PDBsum8bom
PubMed36799129
UniProtP29317|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)

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