Structure of PDB 8bok Chain A

Receptor sequence
>8bokA (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
TTEIHPSCVTRQKVIGAGEVYKGMLKTSKEVPVAIKTLKAGYTEKQRVDF
LGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGE
FSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGL
SRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEV
MTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERAR
RPKFADIVSILDKLIRAPDSLKTLADFDPR
3D structure
PDB8bok Optimization of the Lead Compound NVP-BHG712 as a Colorectal Cancer Inhibitor.
ChainA
Resolution2.02 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R0X A V627 A644 E663 M667 F670 T692 M695 Y735 L746 S756 D757 F758 V20 A34 E53 M57 F60 T82 M85 Y125 L136 S146 D147 F148
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8bok, PDBe:8bok, PDBj:8bok
PDBsum8bok
PubMed36799129
UniProtP29317|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)

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