Structure of PDB 8boi Chain A

Receptor sequence
>8boiA (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
FTTEIHPSCVTRQKVIGAGEFGEVYKGMLKEVPVAIKTLKAGYTEKQRVD
FLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDG
EFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFG
LIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVM
KAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRA
PDSLKTLADFDPRVSIRLP
3D structure
PDB8boi Optimization of the Lead Compound NVP-BHG712 as a Colorectal Cancer Inhibitor.
ChainA
Resolution1.63 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R0O A V627 A644 E663 M667 I690 T692 Y694 M695 V736 H737 L746 V755 S756 D757 F758 V24 A35 E54 M58 I81 T83 Y85 M86 V127 H128 L137 V146 S147 D148 F149
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8boi, PDBe:8boi, PDBj:8boi
PDBsum8boi
PubMed36799129
UniProtP29317|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)

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