Structure of PDB 8boc Chain A

Receptor sequence
>8bocA (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
TTEIHPSCVTRQKVIGAEVYKGMLKTKKEVPVAIKTEKQRVDFLGEAGIM
GQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLV
GMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDD
PEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERP
YWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADI
VSILDKLIRAPDSLKTLADFD
3D structure
PDB8boc Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 19
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QUF A A644 K646 E663 M667 I690 T692 M695 Y735 L746 S756 D757 F758 R762 A33 K35 E46 M50 I73 T75 M78 Y118 L129 S139 D140 F141 R145
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8boc, PDBe:8boc, PDBj:8boc
PDBsum8boc
PubMed36799129
UniProtP29317|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)

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