Structure of PDB 8bm3 Chain A

Receptor sequence

>8bm3A (length=239) Species: 83333 (Escherichia coli K-12)

MRSIARRTAVGAALLLVMPVAVWISGWRWQPGEQSWLLKAAFWVTETVTQ
PWGVITHLILFGWFLWCLRFRIKAAFVLFAILAAAILVGQGVKSWIKDKV
QEPRPFVIWLEKTHHIPVDEFYTLKRAERGNLVKEQLAEEKNIPQYLRSH
WQKETGFAFPSGHTMFAASWALLAVGLLWPRRRTLTIAILLVWATGVMGS
RLLLGMAWPRDLVVATLISWALVAVATWLAQRICGPLTP

3D structure

• PDB: 8bm3 H207A mutant of E. coli PgpB, a PAP2 type phosphatidyl glycerol phosphate and C55-PP phosphatase, in complex with farnesyl pyrophosphate
• Chain: A
• Resolution: 3.5 Å

Enzymatic activity

• Enzyme Commision number: 3.1.3.27: phosphatidylglycerophosphatase.
  3.1.3.4: phosphatidate phosphatase.
  3.6.1.27: undecaprenyl-diphosphate phosphatase.
  3.6.1.75: diacylglycerol diphosphate phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FPP	A	Q50 V54 H57 L87 K97 R104 E154 S161 G162 H163 R201	Q50 V54 H57 L87 K97 R104 E154 S161 G162 H163 R201

Gene Ontology

Molecular Function

• GO:0000810 diacylglycerol diphosphate phosphatase activity
• GO:0008195 phosphatidate phosphatase activity
• GO:0008962 phosphatidylglycerophosphatase activity
• GO:0016787 hydrolase activity
• GO:0050380 undecaprenyl-diphosphatase activity

Biological Process

• GO:0006655 phosphatidylglycerol biosynthetic process
• GO:0009252 peptidoglycan biosynthetic process
• GO:0009395 phospholipid catabolic process
• GO:0046474 glycerophospholipid biosynthetic process

Cellular Component

• GO:0005886 plasma membrane
• GO:0009279 cell outer membrane

External links

• PDB: RCSB:8bm3, PDBe:8bm3, PDBj:8bm3
• PDBsum: 8bm3
• UniProt: P0A924|PGPB_ECOLI Phosphatidylglycerophosphatase B (Gene Name=pgpB)