Structure of PDB 8bin Chain A

Receptor sequence
>8binA (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
TTEIHPSCVTRQKVIGGEVYKGMLKEVPVAIKTLKAGYTEKQRVDFLGEA
GIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVL
QLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVL
EDDGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSN
HEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDK
LIRAPDSLKTLADF
3D structure
PDB8bin Crystal structure of human Ephrin type-A receptor 2 (EPHA2) Kinase domain in complex with MR21
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QRR A V627 A644 I645 K646 E663 T692 Y694 M695 L746 V19 A30 I31 K32 E49 T78 Y80 M81 L132
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8bin, PDBe:8bin, PDBj:8bin
PDBsum8bin
PubMed39028937
UniProtP29317|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)

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