Structure of PDB 8bi6 Chain A

Receptor sequence
>8bi6A (length=355) Species: 9606 (Homo sapiens) [Search protein sequence]
DEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSL
PDTTATLGDEPRKVLLRLYGAAEAMVLESVMFAILAERSLGPKLYGIFPQ
GRLEQFIPSRRLDTEELSLPDISAEIAEKMATFHGMKMPFNKEPKWLFGT
MEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVF
CHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMY
DYSYEKYPFFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIK
EEMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMDYAQARFDAYFHQK
RKLGV
3D structure
PDB8bi6 Crystal structure of human Choline Kinase A in complex with UNC0638
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.32: choline kinase.
2.7.1.82: ethanolamine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A E309 E349 Y352 E207 E247 Y250
BS02 CIQ A D306 Q308 Y354 F361 W420 W423 E434 F435 D204 Q206 Y252 F259 W318 W321 E332 F333
Gene Ontology
Molecular Function
GO:0004103 choline kinase activity
GO:0004104 cholinesterase activity
GO:0004305 ethanolamine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006646 phosphatidylethanolamine biosynthetic process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0006657 CDP-choline pathway
GO:0006869 lipid transport
GO:0008654 phospholipid biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005811 lipid droplet
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8bi6, PDBe:8bi6, PDBj:8bi6
PDBsum8bi6
PubMed
UniProtP35790|CHKA_HUMAN Choline kinase alpha (Gene Name=CHKA)

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