Structure of PDB 8bhs Chain A

Receptor sequence
>8bhsA (length=336) Species: 9606 (Homo sapiens) [Search protein sequence]
NITIFTRILDGLLDGYDNRLRPGLGERITQVRTDMYVNSFGPVSDTEMEY
TIDIFFAQTWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSFAH
WMTTPNRMLRIWNDGRVLYTLRLTISAECPMDLEDFPMDEQNCPLKFGSY
AYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEY
TIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVAARTVFGV
TTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALLEFAFVNYI
TKSQPARAAKIDKMSRIVFPILFGTFNLVYWATYLN
3D structure
PDB8bhs The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors.
ChainA
Resolution3.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QK9 A F103 S162 Y163 T208 T210 Y213 F90 S149 Y150 T195 T197 Y200
BS02 QK9 A Y49 F68 T133 Y36 F55 T120
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004890 GABA-A receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8bhs, PDBe:8bhs, PDBj:8bhs
PDBsum8bhs
PubMed37903907
UniProtP31644|GBRA5_HUMAN Gamma-aminobutyric acid receptor subunit alpha-5 (Gene Name=GABRA5)

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