Structure of PDB 8bfs Chain A

Receptor sequence
>8bfsA (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
WKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKG
KESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIV
EKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKI
MISDFGPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSK
LFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPW
IAGDTALNKNIHESVSAQIRKNFA
3D structure
PDB8bfs Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) in complex with FZ326
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QNR A L29 A50 V82 M98 Q99 L100 V101 S164 L18 A39 V71 M87 Q88 L89 V90 S153
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calcium/calmodulin-dependent protein kinase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0106310 protein serine kinase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007399 nervous system development
GO:0010976 positive regulation of neuron projection development
GO:0016310 phosphorylation
GO:0032793 positive regulation of CREB transcription factor activity
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0050766 positive regulation of phagocytosis
GO:0050773 regulation of dendrite development
GO:0060267 positive regulation of respiratory burst
GO:0071622 regulation of granulocyte chemotaxis
GO:0090023 positive regulation of neutrophil chemotaxis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8bfs, PDBe:8bfs, PDBj:8bfs
PDBsum8bfs
PubMed
UniProtQ8IU85|KCC1D_HUMAN Calcium/calmodulin-dependent protein kinase type 1D (Gene Name=CAMK1D)

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