Structure of PDB 8bem Chain A

Receptor sequence
>8bemA (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
SMKQYEHVKRDLNPEDFWEIIGELGDGGKVYKAQNKETSVLAAAKVIDTK
SEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDA
VMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGD
IKLADFGSFIGTPYWMAPEVVMCETPYDYKADVWSLGITLIEMAEIEPPH
HELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQ
LLQHPFVTVDSNKPIRELIAEAKA
3D structure
PDB8bem STE20-like serine/threonine-protein kinase (SLK) in complex with Tivozanib
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AV9 A V48 A61 E79 I80 I108 C111 G114 A172 D173 F174 V30 A43 E61 I62 I90 C93 G96 A154 D155 F156
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8bem, PDBe:8bem, PDBj:8bem
PDBsum8bem
PubMed
UniProtQ9H2G2|SLK_HUMAN STE20-like serine/threonine-protein kinase (Gene Name=SLK)

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