Structure of PDB 8bdy Chain A

Receptor sequence
>8bdyA (length=190) Species: 9606 (Homo sapiens) [Search protein sequence]
DPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRD
IGKPEVEYDCDNLQHSQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPAS
IPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFN
EMMKVVQVYADDSEVAQAGKAVALYFEDKLTEIYSDRTFA
3D structure
PDB8bdy Exploiting ELIOT for Scaffold-Repurposing Opportunities: TRIM33 a Possible Novel E3 Ligase to Expand the Toolbox for PROTAC Design.
ChainA
Resolution3.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QCU A E981 V986 F1038 E92 V97 F149
BS02 ZN A C902 C905 C931 C19 C22 C48
BS03 ZN A C890 C893 H910 C913 C7 C10 H27 C30
External links
PDB RCSB:8bdy, PDBe:8bdy, PDBj:8bdy
PDBsum8bdy
PubMed36430693
UniProtQ9UPN9|TRI33_HUMAN E3 ubiquitin-protein ligase TRIM33 (Gene Name=TRIM33)

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