Structure of PDB 8bd8 Chain A

Receptor sequence
>8bd8A (length=194) Species: 9606 (Homo sapiens) [Search protein sequence]
PNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDI
GKPEVEYDCDNLQHSKKGKTAQGLSPVDQRKCERLLLYLYCHELSIEFQE
PVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKN
CERFNEMMKVVQVYADSEVAQAGKAVALYFEDKLTEIYSDRTFA
3D structure
PDB8bd8 Exploiting ELIOT for Scaffold-Repurposing Opportunities: TRIM33 a Possible Novel E3 Ligase to Expand the Toolbox for PROTAC Design.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QCU A E981 V986 P987 I990 E97 V102 P103 I106
BS02 ZN A C890 C893 H910 C913 C6 C9 H26 C29
BS03 ZN A C902 C905 C931 C18 C21 C47
External links
PDB RCSB:8bd8, PDBe:8bd8, PDBj:8bd8
PDBsum8bd8
PubMed36430693
UniProtQ9UPN9|TRI33_HUMAN E3 ubiquitin-protein ligase TRIM33 (Gene Name=TRIM33)

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