Structure of PDB 8bc0 Chain A

Receptor sequence
>8bc0A (length=680) Species: 10090 (Mus musculus) [Search protein sequence]
PEFEEFNGKPDSLFFTDGQRRIDFILVYENEKQKRKRQAYESNLICHGLQ
LEATRSVSDDKLVFVKVHAPWEVLCTYAEIMHSFFNPATRSRIVYFILSR
INRLVSSGIYKAAFPLHDCRFSERYLLYREWAHPRSIYKKQPLDLIRKYY
GEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLDQDNCTWSKEVCDPDI
GGQILMCPQCDRLCPFWRLNITCESSKKLCIFDSFGTLIFAVFMGVWVTL
FLEFWKRRQAELEYEWDTVELQQEEQARPEYEAQCKCIRVTLCASAVFFW
ILLIIASVIGIIVYRLSVFIVFSTTPQMATSITASIISAIIIMILNTIYE
KVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVG
YPGDPVYLYRSEECDPGGCLLELTTQLTIIMGGKAIWNNIAEVLLPWVMN
LIGRYKRKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPL
APLLALVNNILEIRVDAWKLTTQFRRMVPEKAQDIGAWQPIMQGIAILAV
VTNAMIIAFTSDMIPRLVYYWSFSIPPYGDHTYYTMDGYINNTLSVFNIT
DFKNENPYIGLGNYTLCRYRDFRNPPGHPQEYKHNIYYWHVIAAKLAFII
VMEHIIYSVKFFISYAIPDVSKITKSKIKR
3D structure
PDB8bc0 Structural basis for the activation of the lipid scramblase TMEM16F.
ChainA
Resolution3.09 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A N620 N621 E624 E699 N438 N439 E442 E512
BS02 CA A E624 E667 E699 D703 E442 E480 E512 D516
BS03 CA A E395 S854 D859 E253 S664 D669
Gene Ontology
Molecular Function
GO:0005227 calcium-activated cation channel activity
GO:0005229 intracellularly calcium-gated chloride channel activity
GO:0005244 voltage-gated monoatomic ion channel activity
GO:0005254 chloride channel activity
GO:0017128 phospholipid scramblase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046983 protein dimerization activity
Biological Process
GO:0002407 dendritic cell chemotaxis
GO:0006821 chloride transport
GO:0006869 lipid transport
GO:0007596 blood coagulation
GO:0017121 plasma membrane phospholipid scrambling
GO:0030501 positive regulation of bone mineralization
GO:0032060 bleb assembly
GO:0034220 monoatomic ion transmembrane transport
GO:0034767 positive regulation of monoatomic ion transmembrane transport
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0035630 bone mineralization involved in bone maturation
GO:0043065 positive regulation of apoptotic process
GO:0045332 phospholipid translocation
GO:0045794 negative regulation of cell volume
GO:0051649 establishment of localization in cell
GO:0060078 regulation of postsynaptic membrane potential
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0061588 calcium activated phospholipid scrambling
GO:0061589 calcium activated phosphatidylserine scrambling
GO:0061590 calcium activated phosphatidylcholine scrambling
GO:0061591 calcium activated galactosylceramide scrambling
GO:0070588 calcium ion transmembrane transport
GO:0090026 positive regulation of monocyte chemotaxis
GO:1902476 chloride transmembrane transport
GO:1903766 positive regulation of potassium ion export across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0034707 chloride channel complex
GO:0097060 synaptic membrane
GO:0098981 cholinergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8bc0, PDBe:8bc0, PDBj:8bc0
PDBsum8bc0
PubMed36335104
UniProtQ6P9J9|ANO6_MOUSE Anoctamin-6 (Gene Name=Ano6)

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