Structure of PDB 8bak Chain A

Receptor sequence
>8bakA (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDK
AHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLD
TYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREE
DRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATD
KWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLIN
NCMDYEPDHRPSFRAIIRDLNSLF
3D structure
PDB8bak Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain.
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AD5 A L579 Q626 E627 F628 V629 K630 G632 K640 L680 L44 Q91 E92 F93 V94 K95 G97 K105 L145
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8bak, PDBe:8bak, PDBj:8bak
PDBsum8bak
PubMed36678572
UniProtO60674|JAK2_HUMAN Tyrosine-protein kinase JAK2 (Gene Name=JAK2)

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