Structure of PDB 8ba5 Chain A

Receptor sequence
>8ba5A (length=134) Species: 9606 (Homo sapiens) [Search protein sequence]
GSRERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLE
CAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQ
AAIDPWNCYMCGHKGTYGLLRRREDWPSRLQMFF
3D structure
PDB8ba5 The MECP2-TRD domain interacts with the DNMT3A-ADD domain at the H3-tail binding site.
ChainA
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C494 C497 C514 C517 C21 C24 C41 C44
BS02 ZN A C537 C540 C559 C562 C64 C67 C86 C89
BS03 ZN A C549 C554 C583 C586 C76 C81 C108 C111
External links
PDB RCSB:8ba5, PDBe:8ba5, PDBj:8ba5
PDBsum8ba5
PubMed36519786
UniProtQ9Y6K1|DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (Gene Name=DNMT3A)

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