Structure of PDB 8b6z Chain A

Receptor sequence
>8b6zA (length=442) Species: 9606 (Homo sapiens) [Search protein sequence]
EKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGS
FKYAWVLDKLKAERERGITIDISLWKFETTKYYITIIDAPGHRDFIKNMI
TGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVN
KMDSTEPAYSEKRYDEIVKEVSAYIKKIGYNPATVPFVPISGWHGDNMLE
PSPNMPWFKGWKVERKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDV
YKIGGIGTVPVGRVETGILRPGMVVTFAPVNITTEVKSVEMHHEALSEAL
PGDNVGFNVKNVSVKDIRRGNVCGDSKSDPPQEAAQFTSQVIILNHPGQI
SAGYSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDNPKSLKSGDAAIVE
MVPGKPMCVESFSQYPPLGRFAVRDMRQTVAVGVIKNVEKKS
3D structure
PDB8b6z Visualization of translation and protein biogenesis at the ER membrane.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A R266 R423 A425 R427 R263 R420 A422 R424
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008135 translation factor activity, RNA binding
GO:0019901 protein kinase binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0043065 positive regulation of apoptotic process
GO:0090218 positive regulation of lipid kinase activity
GO:1904714 regulation of chaperone-mediated autophagy
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005853 eukaryotic translation elongation factor 1 complex
GO:0045202 synapse
GO:0098574 cytoplasmic side of lysosomal membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8b6z, PDBe:8b6z, PDBj:8b6z
PDBsum8b6z
PubMed36697828
UniProtQ05639|EF1A2_HUMAN Elongation factor 1-alpha 2 (Gene Name=EEF1A2)

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