Structure of PDB 8b6l Chain A

Receptor sequence
>8b6lA (length=425) Species: 9606 (Homo sapiens) [Search protein sequence]
IFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPFYWM
RVILELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMII
TIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGY
GLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATR
TDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVDLPIKSYNTY
PIKLFYTSNIPIILQSALVSNLYVISQMLSLLGTWSDRAYPVGGLCYYLS
PPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKE
QQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTG
ILLAVTIIYQYFEIFVKEQSEVGSM
3D structure
PDB8b6l Visualization of translation and protein biogenesis at the ER membrane.
ChainA
Resolution7.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A W34 I37 V44 C45 L150 I161 L164 L165 W31 I34 V41 C42 L127 I138 L141 L142
BS02 peptide A M136 N294 M113 N271
Gene Ontology
Molecular Function
GO:0005048 signal sequence binding
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0008320 protein transmembrane transporter activity
GO:0043022 ribosome binding
Biological Process
GO:0006613 cotranslational protein targeting to membrane
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation
GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane
GO:0007029 endoplasmic reticulum organization
GO:0015031 protein transport
GO:0031204 post-translational protein targeting to membrane, translocation
GO:0039019 pronephric nephron development
GO:0045047 protein targeting to ER
GO:0045048 protein insertion into ER membrane
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005784 Sec61 translocon complex
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8b6l, PDBe:8b6l, PDBj:8b6l
PDBsum8b6l
PubMed36697828
UniProtP61619|S61A1_HUMAN Protein transport protein Sec61 subunit alpha isoform 1 (Gene Name=SEC61A1)

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