Structure of PDB 8b5y Chain A

Receptor sequence
>8b5yA (length=504) Species: 9606 (Homo sapiens) [Search protein sequence]
SRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVT
HIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPL
NCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVR
TGDDKNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVET
LGTVLQLKQPLNTTRINAAEIESRVRELSKLKQGFWEEFETLQQQECKLL
YSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMP
EFKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYW
PDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFR
TWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIV
IDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHY
IETL
3D structure
PDB8b5y Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors.
ChainA
Resolution1.83 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P8O A T108 R111 F113 H114 T218 T219 E249 E250 T253 L254 Q257 K492 Q495 T106 R109 F111 H112 T213 T214 E237 E238 T241 L242 Q245 K471 Q474
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8b5y, PDBe:8b5y, PDBj:8b5y
PDBsum8b5y
PubMed36793438
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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