Structure of PDB 8b4x Chain A

Receptor sequence
>8b4xA (length=473) Species: 9606 (Homo sapiens) [Search protein sequence]
VYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEK
NHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANN
GVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPED
DGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGY
TNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQ
KCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNA
NDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEP
KDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSP
MGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEAN
NYGTLTKFTLVLYGTASGSLVPR
3D structure
PDB8b4x Aminoisoindol-based furin inhibitors
ChainA
Resolution1.6 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.4.21.75: furin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D154 V231 E236 S253 W254 G255 P256 D258 D264 A292 G294 D306 Y308 S368 D46 V123 E128 S145 W146 G147 P148 D150 D156 A184 G186 D198 Y200 S260
BS02 CA A D174 D179 D181 D66 D71 D73
BS03 CA A D115 D162 V205 N208 V210 G212 D7 D54 V97 N100 V102 G104
BS04 CA A D258 D301 E331 D150 D193 E223
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8b4x, PDBe:8b4x, PDBj:8b4x
PDBsum8b4x
PubMed38385828
UniProtP09958|FURIN_HUMAN Furin (Gene Name=FURIN)

[Back to BioLiP]