Structure of PDB 8b4w Chain A

Receptor sequence

>8b4wA (length=472) Species: 9606 (Homo sapiens)

YQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKN
HPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNG
VCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDD
GKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYT
NSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQK
CTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNAN
DWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPK
DIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPM
GTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANN
YGTLTKFTLVLYGTASGSLVPR

3D structure

• PDB: 8b4w Aminoisoindol-based furin inhibitors
• Chain: A
• Resolution: 1.6 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.75: furin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	F05	A	S253 W254 G255 P256 D258 A292 G294 N295 D306 S368	S144 W145 G146 P147 D149 A183 G185 N186 D197 S259
BS02	F05	A	V231 E236 G255 P256 Y308	V122 E127 G146 P147 Y199
BS03	CA	A	D174 D179 D181	D65 D70 D72
BS04	CA	A	D115 D162 V205 N208 V210 G212	D6 D53 V96 N99 V101 G103
BS05	CA	A	D258 D301 E331	D149 D192 E222

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:8b4w, PDBe:8b4w, PDBj:8b4w
• PDBsum: 8b4w
• PubMed: 38385828
• UniProt: P09958|FURIN_HUMAN Furin (Gene Name=FURIN)