Structure of PDB 8b4e Chain A

Receptor sequence
>8b4eA (length=107) Species: 666 (Vibrio cholerae) [Search protein sequence]
KFILAEKFTFDPLSNTLIDKEDSEEIIRLGSNESRILWLLAQRPNEVISR
NDLHDFVWREQGFEVDDSSLTQAISTLRKMLKDSTKSPQYVKTVPKRGYQ
LIARVET
3D structure
PDB8b4e ToxR activates the Vibrio cholerae virulence genes by tethering DNA to the membrane through versatile binding to multiple sites.
ChainA
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A T77 Q78 S81 K85 T91 T99 P101 K102 Y105 T71 Q72 S75 K79 T85 T93 P95 K96 Y99
BS02 dna A G36 N38 S75 Q78 K92 P101 G30 N32 S69 Q72 K86 P95
Gene Ontology
Biological Process
GO:0000160 phosphorelay signal transduction system
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8b4e, PDBe:8b4e, PDBj:8b4e
PDBsum8b4e
PubMed37428913
UniProtP15795|TOXR_VIBCH Cholera toxin transcriptional activator (Gene Name=toxR)

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