Structure of PDB 8b2j Chain A

Receptor sequence
>8b2jA (length=179) Species: 9606 (Homo sapiens) [Search protein sequence]
FNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILL
PLDCGVPDNLSMADPNIRFLDKLPQQTGDRAGIKDRVYSNSIYELLENGQ
RAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADA
PESQNNCRLIAYQFSLSQEVLRHLRQEEK
3D structure
PDB8b2j Crystal structure of human STING in complex with ADU-S100
ChainA
Resolution2.174 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GJF A Y163 Y167 R232 I235 R238 Y240 T263 T267 Y11 Y15 R80 I83 R86 Y88 T111 T115
BS02 CA A N187 N188 R191 N35 N36 R39
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:8b2j, PDBe:8b2j, PDBj:8b2j
PDBsum8b2j
PubMed
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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