Structure of PDB 8b2d Chain A

Receptor sequence

>8b2dA (length=448) Species: 1026882 (Methylophaga aminisulfidivorans MP) [Search protein sequence]

MATRIAILGAGPSGMAQLRAFQSAQEKGAEIPELVCFEKQADWGGQWNYT
WRTGLDENGEPVHSSMYRYLWSNGPKECLEFADYTFDEHFGKPIPSYPPR
EVLWDYIKGRVEKAGVRKYIRFNTAVRHVEFNEDTQTFTVTVQDHTTDTI
YSEEFDYVVCCTGHFSTPYVPEFEGFEKFGGRILHAHDFRDALEFKGKTV
LLVGSSYSAEDIGSQCYKYGAKKVISCYRTAPMGYDWPENWDERPNLVRV
DGENAYFADGSSEKVDAIILCTGYIHHFPFLNDDLRLVTDNRLWPPNLYK
GVVWEDNPKFFYIGMQDQWYSFNMFDAQAWYARDVIMGRIPLPSKEEMKA
DSQAWREREETLKTDEEMYDFQGDYIQDLIDMTDYPSFDIPAVNKTFKEW
KHHKKENIMTFRDHSYRSLMTGTMAPKHHTPWIDALDDSLEAFLSDKS

3D structure

PDB

8b2d Increased Thermostability of an Engineered Flavin-Containing Monooxygenase to Remediate Trimethylamine in Fish Protein Hydrolysates.

Chain

Resolution

1.62 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.13.148: trimethylamine monooxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	G9 G11 P12 S13 E38 K39 Q40 G45 Q46 W47 H63 M66 S72 N73 V126 T162 F165 Q318 S321 F325	G9 G11 P12 S13 E38 K39 Q40 G45 Q46 W47 H63 M66 S72 N73 V126 T162 F165 Q318 S321 F325
BS02	NAP	A	Y67 N73 F165 S205 S206 Y207 S208 D211 R229 N246 C271 T272 G273	Y67 N73 F165 S205 S206 Y207 S208 D211 R229 N246 C271 T272 G273

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0004497	monooxygenase activity
GO:0004499	N,N-dimethylaniline monooxygenase activity
GO:0047822	hypotaurine monooxygenase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

View graph for
Molecular Function

External links

PDB	RCSB:8b2d, PDBe:8b2d, PDBj:8b2d
PDBsum	8b2d
PubMed	37222584
UniProt	F5SYD3

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