Structure of PDB 8b19 Chain A

Receptor sequence
>8b19A (length=451) Species: 562 (Escherichia coli) [Search protein sequence]
QQPRPFFMIFFVELWERFGYYGVQGVLAVFFVKQLGFSQEQAFVTFGAFA
ALVYGLISIGGYVGDHLLGTKRTIVLGALVLAIGYFMTGMSLLKPDLIFI
ALGTIAVGNGLFKANPASLLSKCYPPKDPRLDGAFTLFYMSINIGSLIAL
SLAPVIADRFGYSVTYNLCGAGLIIALLVYIACRGMVKDIGSEPDFRPMS
FSKLLYVLLGSVVMIFVCAWLMHNVEVANLVLIVLSIVVTIIFFRQNKMF
VAFVLMLEAVVFYILYAQMPTSLNFFAINNVHHEILGFSINPVSFQALNP
FWVVLASPILAGILSMPMKFTLGMFMCSLGFLTAAAAGMWFADAQGLTSP
WFIVLVYLFQSLGELFISALGLAMIAALVMGFILGMWFLTQAAAFLLGGY
VATFTAVPDNITDPLETLPVYTNVFGKIGLVTLGVAVVMLLMVPWLKRMI
A
3D structure
PDB8b19 Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition.
ChainA
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R27 Y31 Y64 K123 Y149 I152 N153 S156 Y282 Y285 N318 E393 R17 Y21 Y54 K113 Y139 I142 N143 S146 Y263 Y266 N299 E364
Gene Ontology
Molecular Function
GO:0015078 proton transmembrane transporter activity
GO:0015333 peptide:proton symporter activity
GO:0022857 transmembrane transporter activity
GO:0042937 tripeptide transmembrane transporter activity
GO:0071916 dipeptide transmembrane transporter activity
GO:1904680 peptide transmembrane transporter activity
Biological Process
GO:0006857 oligopeptide transport
GO:0015031 protein transport
GO:0015833 peptide transport
GO:0035442 dipeptide transmembrane transport
GO:0035443 tripeptide transmembrane transport
GO:0042938 dipeptide transport
GO:0042939 tripeptide transport
GO:0055085 transmembrane transport
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8b19, PDBe:8b19, PDBj:8b19
PDBsum8b19
PubMed37467108
UniProtP36837|DTPB_ECOLI Dipeptide and tripeptide permease B (Gene Name=dtpB)

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