Structure of PDB 8ayh Chain A

Receptor sequence
>8ayhA (length=815) Species: 9606 (Homo sapiens) [Search protein sequence]
TLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKA
FTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEV
HLVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEM
NIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSSSKCVRQKV
EGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRES
YSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEIL
SAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDP
LIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQ
VNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEAR
ENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTL
AISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSS
VPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQ
DTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPV
EVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEA
YKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQ
LFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEY
HRPDKQCTMFYSTSN
3D structure
PDB8ayh A small-molecule inhibitor of C5 complement protein.
ChainA
Resolution3.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 H1H A Y700 A703 C704 V705 R739 H744 M747 Q748 G750 R751 M754 Y23 A26 C27 V28 R62 H67 M70 Q71 G73 R74 M77
Gene Ontology
Molecular Function
GO:0004866 endopeptidase inhibitor activity
Biological Process
GO:0006954 inflammatory response
GO:0006956 complement activation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ayh, PDBe:8ayh, PDBj:8ayh
PDBsum8ayh
PubMed31209353
UniProtP01031|CO5_HUMAN Complement C5 (Gene Name=C5)

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