Structure of PDB 8ax5 Chain A

Receptor sequence

>8ax5A (length=549) Species: 9606,83333 [Search protein sequence]

AKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQ
VAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRY
NGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMF
NLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLI
KNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPT
FKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPL
GAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVIN
AASGRQTVDEALKDAQTNAAAEFTTACQEANYGALLRELCLTQFQVDMEA
VGETLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRY
FRSCPIQLGVTRNKIMTAQYECYQKIMQDPIQQVYCQRTWDGWLCWNDVA
AGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASQRTWTNYTQCN

3D structure

PDB

8ax5 Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode.

Chain

Resolution

2.75 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GLC	A	D16 K17 E113 E155 W232	D15 K16 E112 E154 W231
BS02	GLC	A	W64 D67 R68 E155 P156 Y157 W342 R346	W63 D66 R67 E154 P155 Y156 W341 R345
BS03	OKU	A	R1067 A1070 D1071 W1074 W1084 R2038 I2041 M2042 D2070 G2071 W2072 R2119 W2121 T2122 Y2124	R417 A420 D421 W424 W434 R462 I465 M466 D491 G492 W493 R540 W542 T543 Y545

Gene Ontology

	Molecular Function
GO:0004930	G protein-coupled receptor activity
GO:0015026	coreceptor activity
GO:0015144	carbohydrate transmembrane transporter activity

	Biological Process
GO:0006886	intracellular protein transport
GO:0007186	G protein-coupled receptor signaling pathway
GO:0008277	regulation of G protein-coupled receptor signaling pathway
GO:0008643	carbohydrate transport
GO:0055085	transmembrane transport

	Cellular Component
GO:0016020	membrane

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Molecular Function

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Cellular Component

External links

PDB	RCSB:8ax5, PDBe:8ax5, PDBj:8ax5
PDBsum	8ax5
PubMed	36385934
UniProt	O60894\|RAMP1_HUMAN Receptor activity-modifying protein 1 (Gene Name=RAMP1); P0AEX9\|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE); Q16602\|CALRL_HUMAN Calcitonin gene-related peptide type 1 receptor (Gene Name=CALCRL)

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