Structure of PDB 8aw1 Chain A

Receptor sequence
>8aw1A (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
VQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNEV
SQFLTEGIIMKDFSHPNVLSLLGICLRSPLVVLPYMKHGDLRNFIRNETH
NPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFG
LARDMYDKEYDKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAP
PYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSE
LVSRISAIFSTFI
3D structure
PDB8aw1 Biophysical and structural characterization of the impact of c-MET phosphorylation on Tepotinib binding
ChainA
Resolution2.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3E8 A I1084 A1108 L1157 P1158 Y1159 M1160 K1161 D1164 R1208 M1211 A1221 D1222 Y1230 I19 A43 L83 P84 Y85 M86 K87 D90 R134 M137 A147 D148 Y156
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8aw1, PDBe:8aw1, PDBj:8aw1
PDBsum8aw1
PubMed37806493
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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