Structure of PDB 8auw Chain A

Receptor sequence
>8auwA (length=2900) Species: 9606 (Homo sapiens) [Search protein sequence]
EWLVLRDGCMHCDADGLHSLSYHPALNAILAVTSRGTIKVIDGTSGATLQ
ASALSAKPGGQVKCQYISAVDKVIFVDDYAVGCRKDLNGILLLDTALQTP
VSKQDDVVQLELPVTEAQQLLSACLEKVDISSTEGYDLFITQLKDGLKNT
SHETAANHKVAKWATVTFHLPHHVLKSIASAIVNELKKINQNVAALPVAS
SVMDRLSYLLPSARPELGVGPGRSVDRSLMYSEANRRETFTSWPHVGYRW
AQPDPMAQAGFYHQPASSGDDRAMCFTCSVCLVCWEPTDEPWSEHERHSP
NCPFVKGEHTQNVPLSVTLATSPAQFPCTDGTDRISCFGSGSCPHFLAAA
TKRGKICIWDVSKLMKVHLKFEINAYDPAIVQQLILSGAMEVSLDITALS
ILQQPFPCLLAGGLLTYKSPATPLVRRTLPVLLLYSIKESDVFPKPGTLV
QCLRLPKFAEEENLCIDSITPCADGIHLLVGLRTCPVERNVSGGYLVLYK
MNYATRIVTLEEEPIKIQHIKDPQDTITSLILLPPDILDNISTLGHLVIT
TQGGYVKILDLSNFEILAKVEPPKKEGTEEQDTFVSVIYCSGTDRLCACT
KGGELHFLQIGGISGVDLLVDQPFTLEILTSLVELTRFETLTPRFSATVP
PCWVETRTWKLQTDSNSWDEHVFELVLPKACMVGHVDFKFVLNSNITNIP
QIQVTLLKNKAPGLLRLCPFLEDHKEDILCGPVWLASGLDLSGHAGMLTL
TSPKLVKGMAGGKYRSFLIHVKAVNESENLRGCDLLQEVSVTIRRFKKTS
ISKERVQRCAMLQFSEFHEKLVNTLCRKTDDGQITEHAQSLVLDTLCWLA
GVHSNGPGSSKEGNENLLSKTRKFLSDIVRVCFFEAGRSIAHKCARFLAL
CISNGKCDPCQPAFGPVLLKALLDNMSFLPAATTGGSVYWYFVLLNYVKD
EDLAGCSTACASLLTAVSRQLQDTPMEALLQTRYGLYSSPFDPVLFDLEM
SGSEIDLSDVLEGSFTSLTGLLEVEPLHFTCVSTSDGTRIERDDGLALAI
SHASHFLQPPPHQSIIIERMHSGARRFVTLDFGRPILLTDVLIPTCGDLA
SLSIDIWTLGEEVDGRRLVVATDISTHSLILHDLIPPPVCRFMKITVIGR
YGSTNARAKIPLGFYYGHTYILPWESELKNQPEIDQHLAMMVALQEDIQC
RYNLACHRLETLLQSIDLPPLNSANNAQYFLVEEDSRVFSAYQDCIQLQL
QLNLAHNAVQRLKVALGASRKMLSETSNPEDLIQTSSTEQLRTIIRYLLD
TLLSLLHASNGHSVPAVLQSTFHAQACEELFKHLCISGTPKIRLHTGLLL
VQLCGGERWWGQFLSNVLQELYNSEQLLIFPQDRVFMLLSCIGQRSLSNS
GVLESLLNLLDNLLSPLQVLDIPMISWVVMLVSRLLDYVATVEDEANQWS
FINNSRKIRKQLVHHKQQLNLLKAKQKALVEQMEKEKIQSNKGSSYKLLV
EQAKLKQATSKHFKDLIRLRRTFTLAHERCISVVQKLVLFLLSMDFTCHA
DLLLFVCKVLARIANATRPTIHLCEIVNEPQLERLLLLLVGTDFNRGDIS
WGGAWAQYSLTCMLQDILAGELLSVSQALDARLEVGLEQQAELMLKMMST
LEADSILQALTNTSPLSSVPMLNVCFNKLFSMLQVHHVQLESLLQLWLTL
SLNSLYNANRIPVISLNQASITSFLTVLAWYPNTLLRTWCLVLHSLTLMT
NMQLNQESTAHLLVSDPNLIHVLVKFLSGTSPHGTNQHSPQVGPTATQAM
QEFLTRLQVHLSSTCPQIFSEFLLKLIHILSTERGAFQTGQGPLDAQVKL
LEFTLEQNFEVVSVSTISAVIESVTFLVHHYITCSDKVMSRSEMTRDQLM
FDLLKLVNILVQLPLSGPAYVADLVLANQQIMSQILSALGLCNSSISVGD
GLFTILTTLSKKASTVHMMLQPILTYMACGTCQLSEPLLWFILRVLDTSD
ALKAFHDMGGVQLICNNMVTSTRAIVNTARSMVSTIMKFLDGIHNFAPLG
TITSSSPTAQPAEVLLQATPPHRRARSAAWSYIFLPEEAWCDLTIHLPAA
VLLKEIHIQPHLASLATCPSSVSVEVSADGVNMLPLSTPVVTSGLTYIKI
QLVKAEVASAVCLRLHRPRDASTLGLSQIKLLGLTAFGEDQVSKTSIGWL
RLLHHCLTHISDLEGMMASAAAPTANLLQTCAALLMSPYCGMHSPNIEVV
LVKIGLQSTRIGLKLIDILLRNSDSTIDILYQLGTTQDPGTKDRIQALLK
WVSDSARVAAMKTVEYGLLMPSPSHLHCVAAILWHSYELLVEYDLPALLD
QELFELLFNWSMSLPCNMVLKKAVDSLLCSMCHVHPNYFSLLMGWMGITP
LALTESHLATLASSSQSPEAIKQLLDSGLPSLLVRSLASFCFSHISSSES
INKMPITADLVAPILRFLTEVGNSHIMKDWLGGSEVNPLWTALLFLLCHS
GSTGLTTQQRTAIENATVAFFLQCISCHPNNQKLMAQVLCELFQTSPQGN
ISGFIRRLFLQLMLEDEKVTMFLQSPCPLYVIQHPMYGAGHKFRTLHLPV
STTLSDVLDRVITVPVFHLFHKLLAGQPLPAEMTLAQLLTLLYDRKLPQG
YRSIDLTVKLGSRVISLLETCPIQSPLQVFAGMGGLALIAERLIPAHSLA
AFGLFLRLPGYAEVLLKERKHAQCLLRLVLGVLPTLPFHVLRSLFSTTPL
TTDDGVLLRRMALEIGALHLILVCLSALSHHSPRVPRLEEEHVTCLLQVL
ASYINPVSSQNSNALPSVLLELLSQSCLIPAMSSYLRNPLYRALLELLRA
IASCAAMVPLLLPLQTSVGTLLAKMKTCVDLVPDIQKTAEIVYAATTSLR
3D structure
PDB8auw Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.
ChainA
Resolution7.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C328 C331 H348 C355 C275 C278 H295 C302
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0061631 ubiquitin conjugating enzyme activity
Biological Process
GO:0001890 placenta development
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0010466 negative regulation of peptidase activity
GO:0016567 protein ubiquitination
GO:0032465 regulation of cytokinesis
GO:0042127 regulation of cell population proliferation
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0051301 cell division
GO:0060711 labyrinthine layer development
GO:0060712 spongiotrophoblast layer development
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0030496 midbody
GO:0090543 Flemming body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8auw, PDBe:8auw, PDBj:8auw
PDBsum8auw
PubMed36758105
UniProtQ9NR09|BIRC6_HUMAN Baculoviral IAP repeat-containing protein 6 (Gene Name=BIRC6)

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