Structure of PDB 8au3 Chain A

Receptor sequence
>8au3A (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
HIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDND
GKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEG
SPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFV
HRDLAARNCMLDEKFTVKVADFGLARDMYDLPVKWMALESLQTQKFTTKS
DVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYE
VMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHY
3D structure
PDB8au3 Biophysical and structural characterization of the impact of c-MET phosphorylation on Tepotinib binding
ChainA
Resolution2.26 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3E8 A I1084 A1108 P1158 Y1159 M1160 K1161 D1164 R1208 M1211 A1221 D1222 Y1230 I33 A57 P107 Y108 M109 K110 D113 R157 M160 A170 D171 Y179
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8au3, PDBe:8au3, PDBj:8au3
PDBsum8au3
PubMed37806493
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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